Again determined to make adjustment (5)
I believe the answer is:
reset
'make adjustment' is the definition.
Although both the answer and definition are singular nouns, I can't see how they can define each other.
'again determined' is the wordplay.
'again' becomes 're' (prefix meaning 'again').
'determined' becomes 'set' (synonyms).
're'+'set'='RESET'
'to' is the link.
Can you help me to learn more?
(Other definitions for reset that I've seen before include "adjusted" , "do this to make adjustment" , "button on electronic device?" , "Restore to zero" , "Return to original configuration" .)