Again gets weary and gives up work (7)
I believe the answer is:
retires
'gives up work' is the definition.
(I've seen this before)
'again gets weary' is the wordplay.
'again' becomes 're' (prefix meaning 'again').
'gets weary' becomes 'tires' (I've seen this in another clue).
're'+'tires'='RETIRES'
'and' is the link.
(Other definitions for retires that I've seen before include "turns in" , "Pulls out" , "Goes to bed" , "Gives up work" , "Withdraws" .)