Again set up old seat of learning, losing one by park (12)
I believe the answer is:
reconstitute
'old seat of learning losing one by park' is the definition.
I can't judge whether this definition defines the answer.
'again set up' is the wordplay.
'again' becomes 're' (prefix meaning 'again').
'set up' becomes 'constitute'.
're'+'constitute'='RECONSTITUTE'
Can you help me to learn more?
(Other definitions for reconstitute that I've seen before include "Reassemble from parts" , "Restructure" , "Reform" , "Restore" .)