Again signals one's sorrow (7)
I believe the answer is:
remorse
'sorrow' is the definition.
(remorse is a kind of sorrow)
'again signals one's' is the wordplay.
'again' becomes 're' (prefix meaning 'again').
'signals one's' becomes 'morse' (I am not sure about this - if you are sure you should give a lot more credence to this answer).
're'+'morse'='REMORSE'
Can you help me to learn more?
(Other definitions for remorse that I've seen before include "A feeling of deep regret" , "compassion" , "Feeling of guilt" , "Pity" , "display of conscience" .)