Again take up painting after a break (7)
I believe the answer is:
restart
'again take up' is the definition.
('start' can be a synonym for 'take up' so perhaps 'restart' is OK for 'again take up')
'painting after a break' is the wordplay.
'painting' becomes 'art' (painting is an art).
'after' means one lot of letters go next to another.
'a break' becomes 'rest' (a rest is taking a break).
'art' after 'rest' is 'RESTART'.
(Other definitions for restart that I've seen before include "Resume" , "Begin anew" , "begin afresh" , "Jumping the gun will mean" , "Commence again" .)