Agents have no female players (6)
I believe the answer is:
actors
'players' is the definition.
('actor' can be a synonym of 'player')
'agents have no female' is the wordplay.
'agents' becomes 'factors' (I've seen this before).
'have no' indicates named letters should be taken away.
'female' becomes 'f' (abbreviation).
'factors' with 'f' removed is 'ACTORS'.
(Other definitions for actors that I've seen before include "The Gleeson boys, say" , "eg 9 & 11 across" , "They 23 down" , "Cast" , "Luvvies" .)