Crossword Genius

Alienate, lose the affection of (8)

Ross

I believe the answer is:

estrange

(Other definitions for estrange that I've seen before include "Ten gears (anag.)" , "Get cut off" , "Forfeit friendship of, make hostile" , "disunity" , "Become unfriendly towards sergeant" .)

I've seen this clue in the Sydney Morning Herald.
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