Crossword Genius

Alienate new sergeant (8)

Ross

I believe the answer is:

estrange

'alienate' is the definition.
('estrange' can be a synonym of 'alienate')

'new sergeant' is the wordplay.
'new' indicates an anagram.
'sergeant' is an anagram of 'ESTRANGE'.

(Other definitions for estrange that I've seen before include "Ten gears (anag.)" , "Cause to be alienated" , "Get cut off" , "Antagonise using reagents" , "Alienate -- sergeant (anag)" .)

I've seen this clue in The Times.
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