Alienate sergeant in mess (8)
I believe the answer is:
estrange
'alienate' is the definition.
('estrange' can be a synonym of 'alienate')
'sergeant in mess' is the wordplay.
'in mess' is an anagram indicator.
'sergeant' anagrammed gives 'ESTRANGE'.
(Other definitions for estrange that I've seen before include "Alien" , "Cause to become unfriendly using reagents" , "Ten gears (anag.)" , "Divorce" , "split up?" .)