Alienate troubled sergeant (8)
I believe the answer is:
estrange
'alienate' is the definition.
('estrange' can be a synonym of 'alienate')
'troubled sergeant' is the wordplay.
'troubled' is an anagram indicator.
'sergeant' with letters rearranged gives 'ESTRANGE'.
(Other definitions for estrange that I've seen before include "disunity" , "Divorce" , "Make enemy of sergeant" , "Alien" , "Get on the wrong side of" .)