Alienated (9)
'alienated' is the definition.
('estrange' can be a synonym of 'alienate')
This is the entire clue.
(Other definitions for estranged that I've seen before include "Alienated, disaffected" , "no longer friendly" , "Sad regent (anag) - disaffected" , "Having become unfriendly or alienated" , "Cut off" .)
'alienated' is the definition.
('disaffect' can be a synonym of 'alienate')
This is all the clue.
(Other definitions for disaffected that I've seen before include "Out of sympathy with those in power" , "Rebellious" , "No longer supporting those in power" , "Alienated from authority" , "No longer willing to support those in authority" .)