Alienated journalist full of rum (9)
I believe the answer is:
estranged
'alienated' is the definition.
('estrange' can be a synonym of 'alienate')
'journalist full of rum' is the wordplay.
'journalist' becomes 'ed' (short for editor).
'full of' indicates putting letters inside.
'rum' becomes 'strange' ('strange' can be a synonym of 'rum'**).
'ed' enclosing 'strange' is 'ESTRANGED'.
(Other definitions for estranged that I've seen before include "Split" , "Having become unfriendly or alienated" , "A nerd gets (anag) - separated" , "Sad regent (anag) - disaffected" , "no longer friendly" .)