All the changes here are deadly (6)
I believe the answer is:
lethal
'are deadly' is the definition.
(synonyms)
'all the changes' is the wordplay.
'changes' is an anagram indicator.
'all'+'the'='allthe'
'allthe' anagrammed gives 'LETHAL'.
'here' is the link.
I am not very happy about this link. It may belong to another bit of the clue.
Can you help me to learn more?
(Other definitions for lethal that I've seen before include "--- Weapon, Mel Gibson film" , "Destructive" , "bringing down the curtain" , "Terminal" , "very nasty indeed" .)