Almost a quarter premature (6)
I believe the answer is:
nearly
'almost' is the definition.
('nearly' can be a synonym of 'almost')
'a quarter premature' is the wordplay.
'a quarter' becomes 'n'.
'premature' becomes 'early' ('early' can be similar in meaning to 'premature').
'n'+'early'='NEARLY'
(Other definitions for nearly that I've seen before include "More or less" , "Almost, not quite" , "approximately" , "parsimoniously" , "Almost, well-nigh" .)