Almost approximate what's commonest in genetic make-up (5)
I believe the answer is:
rouge
'make-up' is the definition.
(I know that rouge is a type of make-up)
'almost approximate what's commonest in' is the wordplay.
'almost' means to remove the last letter (almost the whole word is kept).
'approximate' becomes 'rough' (I've seen this in another clue).
'what's commonest in' becomes 'e' (I can't explain this - if you can you should give a lot more credence to this answer).
'rough' with its final letter removed is 'roug'.
'roug'+'e'='ROUGE'
'genetic' acts as a link.
This may not be right. It may belong to another bit of the clue.
Can you help me to learn more?
(Other definitions for rouge that I've seen before include "Reddish cosmetic for colouring cheeks" , "Rumpled, disordered" , "Cheek powder" , "See 1" , "Cosmetic for reddening cheeks" .)