Always burdened by misfortunes? Absolutely right! (3,3)
I believe the answer is:
i'll say
'absolutely right' is the definition.
'always burdened by misfortunes?' is the wordplay.
'always' becomes 'ay'.
'burdened by' is a charade indicator (letters next to each other) (in a down clue, some letters are carried by others).
'misfortunes?' becomes 'ills' (ill is a kind of misfortune).
'ay' after 'ills' is 'ILL SAY'.
I've seen this clue in The Independent.
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