Ambrose regularly ignored wife (3)
I believe the answer is:
mrs
'wife' is the definition.
(Mrs is an example)
'ambrose regularly ignored' is the wordplay.
'regularly ignored' means one should take alternating letters.
The alternate letters of 'ambrose' are 'MRS'.
(Other definitions for mrs that I've seen before include "She's married" , "Address for married women" , "An abbreviated married woman" , "In brief, a married woman" , "Call the married woman" .)