American dons in demand running space centre (7)
I believe the answer is:
houston
'space centre' is the definition.
The answer and definition can be both locations as well as being singular nouns.
Perhaps you can see a link between them that I can't see?
'american dons in demand running' is the wordplay.
'american' becomes 'US' (United States).
'dons' is an insertion indicator (don means to wear or put on).
'in demand' becomes 'hot' (I've seen this in another clue).
'running' becomes 'on' (eg when a machine is running it is on).
'us' placed inside 'hot' is 'houst'.
'houst'+'on'='HOUSTON'
Can you help me to learn more?
(Other definitions for houston that I've seen before include "Tell them we have a problem" , "Texas city (with a problem?)" , "Oh, not us! (anag) - US city" , "American place" , "Texas oil port" .)