American in the nude, perhaps, getting fresh (6)
I believe the answer is:
unused
'fresh' is the definition.
(thesaurus)
'american in the nude perhaps' is the wordplay.
'american' becomes 'us'.
'in the' is an insertion indicator.
'perhaps' indicates anagramming the letters.
'nude' with letters rearranged gives 'uned'.
'us' inserted inside 'uned' is 'UNUSED'.
'getting' acts as a link.
(Other definitions for unused that I've seen before include "'Fresh, new (6)'" , "Still in wrapper?" , "Surplus" , "Mint, as new" , "Not accustomed to" .)