American in the nude, perhaps, getting fresh (6)
I believe the answer is:
unused
'fresh' is the definition.
(I've seen this before)
'american in the nude perhaps' is the wordplay.
'american' becomes 'US' (abbreviation for United States).
'in the' means one lot of letters goes inside another.
'perhaps' is an anagram indicator.
'nude' anagrammed gives 'uned'.
'us' placed into 'uned' is 'UNUSED'.
'getting' is the link.
(Other definitions for unused that I've seen before include "'Fresh, new (6)'" , "Still in wrapper?" , "Surplus" , "Mint, as new" , "Not accustomed to" .)