American leader getting cheeky again (6)
I believe the answer is:
afresh
'again' is the definition.
(synonyms)
'american leader getting cheeky' is the wordplay.
'american leader getting' becomes 'a' (I can't justify this - if you can you should give a lot more credence to this answer).
'cheeky' becomes 'fresh' (I've seen this before).
'a'+'fresh'='AFRESH'
Can you help me to learn more?
(Other definitions for afresh that I've seen before include "Anew, from the beginning" , "In a new way" , "In a different way" , "Academy award" , "Newly" .)