American man on street upset Girl Guides (10)
I believe the answer is:
usherettes
'girl guides' is the definition.
(female ushers)
'american man on street upset' is the wordplay.
'american man' becomes 'ushe' (I am not sure about this - if you are sure you should believe this answer much more).
'on' is a charade indicator (letters next to each other).
'upset' indicates an anagram.
'street' is an anagram of 'rettes'.
'ushe'+'rettes'='USHERETTES'
Can you help me to learn more?
(Other definitions for usherettes that I've seen before include "Guides" , "female escorts" .)