American name tag is held by a single needle (10)
I believe the answer is:
antagonise
'needle' is the definition.
(both can mean to provoke or irritate somebody)
'american name tag is held by a single' is the wordplay.
'american' becomes 'a' (common abbreviation - e.g. in organisation names).
'name' becomes 'n' (common abbreviation e.g. on forms).
'held by' is an insertion indicator.
'a single' becomes 'one' (a single thing - only one).
'is' placed within 'one' is 'onise'.
'a'+'n'+'tag'+'onise'='ANTAGONISE'
(Other definitions for antagonise that I've seen before include "Make an enemy of" , "Bug" , "Provoke hostility" , "anger" , "Create hostility" .)