An amount of poison directed at team, Guardiola's team (8)
I believe the answer is:
toxicity
'an amount of poison' is the definition.
I can't tell whether this definition defines the answer.
'directed at team guardiola's team' is the wordplay.
'directed at' becomes 'to'.
'team' becomes 'xi' (eleven, a football team).
'guardiola's team' becomes 'city' (I can't explain this - if you can you should believe this answer much more).
'to'+'xi'+'city'='TOXICITY'
Can you help me to learn more?
(Other definitions for toxicity that I've seen before include "Strength of poison" , "Deadly strength" , "Dangerous condition" .)