An honour to accept Orbison's first instrument (4)
I believe the answer is:
oboe
'instrument' is the definition.
(oboe is a kind of instrument)
'an honour to accept orbison's first' is the wordplay.
'an honour' becomes 'obe'.
'to accept' is an insertion indicator.
'first' suggests taking the first letters.
The first letter of 'orbison' is 'o'.
'obe' enclosing 'o' is 'OBOE'.
(Other definitions for oboe that I've seen before include "Source of music" , "Cor anglais in its family" , "Double-reed woodwind" , "Instrument used in 1d" , "music producer" .)