Andre gets terribly alienated (9)
I believe the answer is:
estranged
'alienated' is the definition.
(I know that alienated can be written as estranged)
'andre gets terribly' is the wordplay.
'terribly' indicates anagramming the letters.
'andre'+'gets'='andregets'
'andregets' anagrammed gives 'ESTRANGED'.
(Other definitions for estranged that I've seen before include "Sad regent (anag) - disaffected" , "Having become unfriendly or alienated" , "A nerd gets (anag) - separated" , "no longer friendly" , "Cut off" .)