Andrew may become a college head (6)
I believe the answer is:
warden
'a college head' is the definition.
(I've seen this before)
'andrew may become' is the wordplay.
'may become' indicates anagramming the letters.
'andrew' is an anagram of 'WARDEN'.
(Other definitions for warden that I've seen before include "Caretaker" , "Warned about supervisory official" , "Custodian" , "Supervisor; governor" , "Andrew, strangely, is in prison" .)