Anger starts to infuse Roman Empire (3)

I believe the answer is:

ire

'anger' is the definition.
(ire is intense rage)

'starts to infuse roman empire' is the wordplay.
'starts to' says to take the initial letters.
The first letters of 'infuse roman empire' is 'IRE'.

(Other definitions for ire that I've seen before include "Anger, rage" , "'Anger, wrath (3)'" , "Intense anger" , "Choler" , "Outrage" .)

I've seen this clue in The Times.

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