Angry and very rude on vacation (4)
I believe the answer is:
sore
'angry' is the definition.
('sore' can be similar in meaning to 'angry')
'very rude on vacation' is the wordplay.
'very' becomes 'so' (I've seen this in other clues).
'on vacation' means to remove the middle letters.
'rude' with its middle removed is 're'.
'so'+'re'='SORE'
'and' acts as a link.
(Other definitions for sore that I've seen before include "To be very old" , "source of distress" , "Eros (anag.)" , "See 16" , "Painful, or the source of pain" .)