Angry with a charge at the medical centre (5)
I believe the answer is:
irate
'angry' is the definition.
('irate' can be similar in meaning to 'angry')
'a charge at the medical centre' is the wordplay.
'a charge' becomes 'rate' (rate is a kind of charge**).
'at' means one lot of letters go next to another (I've seen this in other clues).
'centre' means to look at the middle letters.
The middle letter of 'medical' is 'i'.
'rate' after 'i' is 'IRATE'.
'with' acts as a link.
(Other definitions for irate that I've seen before include "Annoyed, irritated" , "Wrathful" , "Annoyed, nettled" , "Indignant, angry" , "ranting" .)