Anguish; hardship (8)
I believe the answer is:
distress
I believe this clue is a double definition.
'anguish' is the first definition.
(I've seen this before)
'hardship' is the second definition.
(distress is a kind of hardship)
(Other definitions for distress that I've seen before include "State of suffering" , "Pain, trouble or sorrow" , "Pressure of pain or sorrow" , "Anguish - trouble - danger" , "Adversity" .)