Animal more fashionable in the East End? (5)
I believe the answer is:
otter
'animal' is the definition.
(I know that otter is a type of animal)
'more fashionable in the east end?' is the wordplay.
'more fashionable' becomes 'hotter'.
'in the east end?' means to remove the first letter (drop a letter, as a cockney might).
'hotter' with its initial letter removed is 'OTTER'.
(Other definitions for otter that I've seen before include "River creature" , "furry creature" , "Fish-eating mammal" , "Holt dweller" , "Aquatic beast" .)