Animosity from wicked family (3,5)
I believe the answer is:
bad blood
'animosity' is the definition.
(synonyms)
'wicked family' is the wordplay.
'wicked' becomes 'bad' (associated in meaning).
'family' becomes 'blood' (blood can mean one's family).
'bad'+'blood'='BAD BLOOD'
'from' acts as a link.
(Other definitions for bad blood that I've seen before include "Ill feeling of tainted sanguinary sort" , "Hatred - ill-feeling" , "Feeling of animosity or hostility" , "Hostility, ill feeling of sanguinary kind" , "Rancour" .)