Annoy pair holding frame of Renoir at gallery (8)
I believe the answer is:
irritate
'annoy' is the definition.
(I know that annoy can be written as irritate)
'pair holding frame of renoir at gallery' is the wordplay.
'pair' becomes 'ii' (I can't justify this - if you can you should believe this answer much more).
'holding' indicates putting letters inside.
'frame of' means to remove the middle letters (use the outside letters which frame the word).
'at' means one lot of letters go next to another.
'gallery' becomes 'tate' (Tate Modern, Tate Britain etc).
'renoir' with its centre taken out is 'rr'.
'ii' going around 'rr' is 'irri'.
'irri'+'tate'='IRRITATE'
Can you help me to learn more?
(Other definitions for irritate that I've seen before include "Needle" , "bug" , "Nark" , "Anger, annoy" , "Vex, aggravate" .)