Annoy river snake (7)
I believe the answer is:
rattler
'snake' is the definition.
(I know that rattler is a type of Crotalinae)
I can't explain the rest of the clue.
Can you help me to learn more?
(Other definitions for rattler that I've seen before include "Dangerous snake" , "that makes one frightened" , "American pit viper (informal)" , "old crate" , "North American pit viper" .)