Annoyance to the royals? That's heartless and unkind (4)
I believe the answer is:
mean
'unkind' is the definition.
(I've seen this before)
I don't understand the rest of the clue.
(Other definitions for mean that I've seen before include "'Midway, average (4)'" , "middle course" , "spell" , "Spiteful -- excellent (slang)" , "Common" .)