Annoyed, struggling for pain relief (7)
I believe the answer is:
anodyne
'pain relief' is the definition.
'annoyed struggling' is the wordplay.
'struggling' indicates anagramming the letters.
'annoyed' anagrammed gives 'ANODYNE'.
'for' acts as a link.
(Other definitions for anodyne that I've seen before include "Unlikely to offend" , "not causing disagreement" , "Analgesic; bland" , "Annoyed, being pain reliever" , "Soothing to the mind or feelings" .)