Annoyed with lag: 60 minutes upset one with thick skin (10)
I believe the answer is:
rhinoceros
'skin' is the definition.
The definition and answer can be both animals as well as being singular nouns.
Maybe you can see a link between them that I can't see?
I don't understand the rest of the clue.
Can you help me to learn more?
(Other definitions for rhinoceros that I've seen before include "Horned mammal" , "Ionesco's work" , "Thick-skinned beast" , "Big game" , "Large horned animal" .)