Crossword Genius

Answer is held by male in discomfort (7)

Ross

I believe the answer is:

malaise

'discomfort' is the definition.
(I know that malaise is a type of discomfort)

'answer is held by male' is the wordplay.
'answer' becomes 'a' (abbreviation eg in Q and A).
'held by' means one lot of letters goes inside another.
'a'+'is'='ais'
'ais' going inside 'male' is 'MALAISE'.

'in' acts as a link.

(Other definitions for malaise that I've seen before include "Out-of-sorts feeling" , "flu perhaps" , "General feeling of discomfort" , "Unease; lethargy" , "depression" .)

I've seen this clue in The Sun.
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