Crossword Genius

Antagonise English eccentric (8)

Ross

I believe the answer is:

estrange

'antagonise' is the definition.
(I've seen this before)

'english eccentric' is the wordplay.
'english' becomes 'e' (abbreviation).
'eccentric' becomes 'strange' (synonyms).
'e'+'strange'='ESTRANGE'

(Other definitions for estrange that I've seen before include "turn away?" , "Antagonise using reagents" , "Anger set (anag.)" , "Lose friendship" , "Cause to become unfriendly using reagents" .)

I've seen this clue in The Telegraph.
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