Antelopes from eastern districts (6)
I believe the answer is:
elands
'antelopes' is the definition.
(eland is a kind of antelope)
'eastern districts' is the wordplay.
'eastern' becomes 'e'.
'districts' becomes 'lands' (land is a kind of district).
'e'+'lands'='ELANDS'
'from' acts as a link.
(Other definitions for elands that I've seen before include "Large African antelopes" , "Animals" , "African antelopes with twisted horns" .)