Anxious female with expression of disgust trapped by rodent (7)
I believe the answer is:
fraught
'anxious' is the definition.
(I've seen this before)
'female with expression of disgust trapped by rodent' is the wordplay.
'female' becomes 'f' (abbreviation).
'with' is a charade indicator (letters next to each other).
'expression of disgust' becomes 'ugh' (I've seen this before).
'trapped by' is an insertion indicator.
'rodent' becomes 'rat' (rat is a kind of rodent).
'ugh' going inside 'rat' is 'raught'.
'f'+'raught'='FRAUGHT'
(Other definitions for fraught that I've seen before include "Emotionally charged" , "anxious" , "Charged (with); tense" , "great anxiety" , "Causing stress" .)