Anxious nipper heaves up (12)
I believe the answer is:
apprehensive
'anxious' is the definition.
(synonyms)
'nipper heaves up' is the wordplay.
'up' is an anagram indicator (letters get chucked up).
'nipper'+'heaves'='nipperheaves'
'nipperheaves' anagrammed gives 'APPREHENSIVE'.
(Other definitions for apprehensive that I've seen before include "Seven happier (anag.)" , "Worried" , "Fearful, anxious" , "Uneasy, anxious" , "Feeling anxiety or fear about future events" .)