Anxious, on edge over Vaslav Nijinsky's last letters (5)
I believe the answer is:
nervy
'anxious' is the definition.
(I've seen this before)
'on edge over vaslav nijinsky's last letters' is the wordplay.
'last letters' suggests the final letters.
The final letters of 'on edge over vaslav nijinsky' are 'NERVY'.
(Other definitions for nervy that I've seen before include "Fidgety" , "Highly strung" , "Highly-strung" , "On edge, tense" , "Easily agitated, tense" .)