Any about to depart may give hurt (5)
I believe the answer is:
agony
'give hurt' is the definition.
'agony' can be an answer for 'hurt' (synonyms). I'm unsure of the 'give' bit.
'any about to depart' is the wordplay.
'about' indicates putting letters inside.
'to depart' becomes 'go' ('go' can be a synonym of 'depart').
'any' placed around 'go' is 'AGONY'.
'may' is the link.
Can you help me to learn more?
(Other definitions for agony that I've seen before include "Severe pain, mental or physical" , "woe" , "This aunt answers readers' questions" , "Extreme suffering - kind of aunt" , "Excruciating pain" .)