Any garbled arrangement, generally (2,3,5)
I believe the answer is:
by and large
'generally' is the definition.
(I know that generally can be written as by and large)
'any garbled arrangement' is the wordplay.
'arrangement' is an anagram indicator.
'any'+'garbled'='anygarbled'
'anygarbled' with letters rearranged gives 'BY AND LARGE'.
(Other definitions for by and large that I've seen before include "Speaking generally" , "In the main" , "As a rule" , "On the whole" , "In general" .)