Appear so upset about old long-running series (4,5)
I believe the answer is:
soap opera
'long-running series' is the definition.
'appear so upset about old' is the wordplay.
'upset' indicates an anagram.
'about' indicates putting letters inside.
'old' becomes 'o' (common abbreviation eg in OE for Old English).
'appear'+'so'='appearso'
'appearso' with letters rearranged gives 'soappera'.
'soappera' placed around 'o' is 'SOAP-OPERA'.
(Other definitions for soap opera that I've seen before include "Long-running story supposedly true to life" , "Eg, Coronation Street" , "TV programme" , "TV serial such as Coronation Street" , "Television serial" .)