Approach female upstart right away after taking the lead (6)
I believe the answer is:
avenue
'approach' is the definition.
(both can refer to a road)
I don't understand the rest of the clue.
Can you help me to learn more?
(Other definitions for avenue that I've seen before include "Road leading to a house" , "Wide street or path to progress" , "A line of approach" , "Entrance passage" , "A broad thoroughfare as in New York" .)