Appropriate, regarding the eastern Mediterranean (8)
I believe the answer is:
relevant
'appropriate' is the definition.
(thesaurus)
'regarding the eastern mediterranean' is the wordplay.
'regarding' becomes 're'.
'the eastern mediterranean' becomes 'levant' (I've seen this before).
're'+'levant'='RELEVANT'
(Other definitions for relevant that I've seen before include "Apposite" , "Bearing on the issue in hand" , "To the point" , "Appropriate" , "Closely connected (to the matter in hand)" .)