Article we picked up again (4)
I believe the answer is:
anew
'again' is the definition.
(I've seen this before)
'article we picked up' is the wordplay.
'article' becomes 'an' (indefinite article).
'picked up' shows that the letters should be reversed in order.
'we' back-to-front is 'ew'.
'an'+'ew'='ANEW'
(Other definitions for anew that I've seen before include "Again but differently" , "Afresh" , "From the beginning again" , "Wane in a different way, again" , "Once more (poetic)" .)