Artist with sense drinking my bitter (9)
I believe the answer is:
rancorous
'bitter' is the definition.
(synonyms)
'artist with sense drinking my' is the wordplay.
'artist' becomes 'RA' (Royal Academician, member of Royal Academy of Arts).
'with' is a charade indicator (letters next to each other).
'sense' becomes 'nous' (nous is a kind of sense).
'drinking' is an insertion indicator (inserted letters are consumed or drunk).
'my' becomes 'cor' (both are expressions of surprise).
'nous' going around 'cor' is 'ncorous'.
'ra'+'ncorous'='RANCOROUS'
(Other definitions for rancorous that I've seen before include "Acrimonious" , "Showing bitter resentment" , "spiteful?" , "Resentful, bitter" .)